Ultrasound enhances gene therapy for tumors button
High intensity focused ultrasound emitted in short pulses is a promising non-invasive delivery of genes to improve the cancer cells without destroying healthy tissue, according to a study published in the May issue of the journal Radiology. High intensity focused ultrasound (HIFU) is more powerful than standard ultrasound. HIFU can destroy tumors through long and continuous exposures that raise the temperature inside cancerous cells, effectively firing. Under a technique introduced by King C.P. Li, MD, MBAexposed tissue to prevent hot and damaged. Pulsed-HIFU instead makes tissues permeable and helps target for the beginning of genes and other therapeutic substances injected into the body. In practice, they were open to using sound waves into the tissue by producing gaps
between the cells, making it leakier and more likely to take several genes, agents and compounds, Victor Frenkel, Ph.D., a researcher said for the diagnostic radiology department of the NIH Clinical Center in Bethesda, MarylandWorking with leading authors Cristina M. Dittmar, MD, and Jianwu Xie, MD, used the momentum of researchers HIFU on tumors in mice, and then immediately injected an easily measurable reporter gene into the tail vein. The reporter gene in this study - a green fluorescent protein in the deep-sea invertebrates - was visible in all areas of tumors exposed to pulsed HIFU. Tumors that are not under the impetus of the HIFU showed negligible signs of the gene.
not exposed. The researchers were encouraged by the results, especially because the type of
cancer treated in the study - squamous cell carcinoma, which is found in tumors of the head and neck - cancer is one of the less permeable and does not respond well to chemotherapy or radiation. However, these types of tumors have responded to certain types of therapeutic genes. This procedure is hypothetically generic for improved delivery of all tissues, Dr. Frenkel said. Previous studies by Dr. Li have shown that pulsed Pages: [1] 2